August 29, 2014

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TLSR: Mike, your large biopharma, Celgene, will be represented at ASH, and you will also see smallercap businesses represented there. Do you see these companies watching their possible competitors' displays? MK: Sure. Completely. A business like Celgene might have 100 individuals in the room. These are the researchers down in the trenches. You don't know who nike air force 1 billigt they are simply because they are not people you recognizeand some of these lecture halls, as you might imagine, are mammoth. I frequently sit down in the front because I don't want to miss something, and generally the entrance section is packed with my sellside competition or some of my buyside customers. Everyone else generally hangs back. It is not usually simple to discover people to ask questions of, and that's why you have investor meetings at these scientific conferences. You might talk to some investigators and be able to ask them about their competitors. TLSR: Mike, let us talk about some companies. Previously you talked about Epizyme, which grew to become a public company ralph lauren outlet sverige in the spring. Would you like to expand on that comment? MK: Yes. Epizyme is in epigenetics, an area that I truly like. Epigenetics is the targeting of the modulators of gene expression. They inhibit DNA methyltransferase, which prevents methylation of cytosine, 1 of the four bases making up the DNA molecule. These methyl teams maintain genes that should be expressing proteins silent. Dacogen, SGI110 and Celgene's Vidaza try to get a tumor to reexpress genes that have been aberrantly silenced because the cell has turn out to be cancerous. Ordinarily, a mobile will upregulate a gene that will destroy that mobile when it detects some type of DNA damage. But that gene may have been silenced by the most cancers and consequently the billiga air force 1 cell cannot kill itself. Alongside comes Dacogen, Vidaza or SGI110, which unsilences the gene through hypomethylation, and the tumor mobile then blows up and dies. This system has not been as widely explored as other targeted agents designed to interrupt the cell signaling and growth aspect pathways. TLSR: What about Epizyme's platform? How does it vary from the hypomethylation mechanism of Dacogen, SGI110 or Vidaza? MK: Epizyme has labored to inhibit what is known as histone methyltransferases [HMTs], which are enzymes that put methyl markings on the amino acids that make up the histone entities around which DNA strands wrap themselves. These markers can regulate genes. polo ralph lauren outlet sverige If you appear at Epizyme's two programs, EPZ5676 and EPZ6438, you will see two drugs focusing on specific mutations in these proteins. The kind of reaction prices that we would anticipate to see are much more in line with the focused brokers that hit tyrosine kinases, like Pharmacyclics' ibrutinib or Ariad's Iclusig, which strike the genetic mutation in louis vuitton väska rea chronic myeloid leukemia that knocks out signaling pathways. What we like about Epizyme is not only its substantial firstmover advantage but also, like Ariad and Pharmacyclics before it, the company is focusing on

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